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authorOlivier Fisette <ribosome@gentoo.org>2004-12-23 16:05:37 +0000
committerOlivier Fisette <ribosome@gentoo.org>2004-12-23 16:05:37 +0000
commita105093e757caa587a26c442dea96126c4ba8a7f (patch)
tree686b6cc38b2a668a60d8765c2ae12eee929c4e70 /sci-biology/sim4/metadata.xml
parentMoving to sci-biology/sim4 (diff)
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Moved from app-sci/sim4 to sci-biology/sim4.
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+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "http://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+ <maintainer>
+ <email>ribosome@gentoo.org</email>
+ <name>Olivier Fisette</name>
+ </maintainer>
+ <herd>sci</herd>
+ <longdescription>
+ sim4 is a similarity-based tool for aligning an expressed DNA sequence
+ (EST, cDNA, mRNA) with a genomic sequence for the gene. It also detects
+ end matches when the two input sequences overlap at one end (i.e., the
+ start of one sequence overlaps the end of the other).sim4 employs a
+ blast-based technique to first determine the basic matching blocks
+ representing the "exon cores". In this first stage, it detects all
+ possible exact matches of W-mers (i.e., DNA words of size W) between
+ the two sequences and extends them to maximal scoring gap-free
+ segments. In the second stage, the exon cores are extended into the
+ adjacent as-yet-unmatched fragments using greedy alignment algorithms,
+ and heuristics are used to favor configurations that conform to the
+ splice-site recognition signals (GT-AG, CT-AC). If necessary, the
+ process is repeated with less stringent parameters on the unmatched
+ fragments.
+ </longdescription>
+</pkgmetadata>